About this job

An exciting opportunity has arisen for a Protein NMR Spectroscopist to join our client; a leading drug discovery organisation focused on developing therapeutic solutions for oncology and CNS disorders.

In this position, you will play a key part in supporting a fragment-based drug discovery (FBDD) platform, using advanced NMR techniques to investigate protein–ligand interactions and drive early-stage drug discovery projects.

Key Responsibilities

• Develop and optimise protein- and ligand-observed NMR assays
• Conduct NMR-based fragment screening campaigns
• Characterise hits and generate data on binding affinity, kinetics, and mechanism of action
• Prepare isotopically labelled protein samples (expression & purification)
• Analyse and present data to multidisciplinary project teams

Key experience:

• Strong expertise in protein NMR spectroscopy; either from academia or industry experience
• Experience of troubleshooting & maintaining NMR spectroscopy instruments

• Solid understanding of protein–ligand interactions and biophysics
• Ability to work independently and communicate effectively within cross-functional teams

• Fragment-based or structure-based drug discovery experience is desirable
• Experience with other biophysical techniques such as SPR, ITC, MS is desirable