Senior Scientist - Immune Reset

Our client, a leading global biopharmaceutical organisation, is seeking a Research Scientist/Senior Scientist to join its Immune Reset team.

This is a hands-on role focused on developing and executing translational and functional in vitro/ex vivo assays using primary human immune cells and patient-derived samples. You will generate data supporting target validation, molecule selection and translational development programmes.

Key Responsibilities

Develop, optimise and execute functional immune-cell assays for screening, target validation and mechanism-of-action studies. Develop translational assays using primary human immune cells and patient samples. Analyse data, troubleshoot experiments and communicate clear scientific conclusions. Present findings to multidisciplinary and cross-functional teams. Collaborate across biology, translational science and data science. Work to high standards of laboratory safety, compliance and sample governance.

Essential Experience

BSc/MSc/PhD in Immunology, Cell Biology, Molecular Biology or a related discipline. Strong knowledge of human immunology and autoimmune disease biology. Hands-on experience with functional immune-cell assays, such as proliferation, activation, cytotoxicity, differentiation, MLR or antigen-recall assays. Experience with Fc-mediated mechanisms such as ADCC, ADCP and/or CDC. Experience isolating and culturing primary human immune-cell subsets using FACS and/or magnetic separation. Strong multiparameter flow cytometry expertise, including panel design, controls, compensation/spectral unmixing and data analysis. Experience with platforms such as ELISA, MSD, Luminex or ELISpot. Proficiency with FlowJo, GraphPad Prism, Excel and/or R. Strong analytical, troubleshooting and communication skills.

Desirable

Patient-derived autoimmune/inflammatory disease samples. B-cell, T-cell, plasma-cell or myeloid biology. Biologics or other therapeutic modalities. Spectral flow, single-cell, imaging, transcriptomics or proteomics.

This is an excellent opportunity to join a scientifically ambitious organisation working at the forefront of immune modulation and immune reset.

If this sounds like the role for you then apply now!

Keywords: Flow cytometry, FACS, biomarker, translational science, Immune reset, autoimmune,, immunology, research, method development, assay development, senior, Research, scientist, Slough, London, Reading, Oxford, Berkshire, Surrey, VRS9543DT

Please note that by submitting your application to VRS Ltd your details will be registered with us so that we can contact you about suitable job opportunities now and in future. You may unsubscribe at any time by emailing us directly via our website.